Length does not matter: a new take on telomerase reverse transcriptase.

نویسندگان

  • Wendy A Goodman
  • Mukesh K Jain
چکیده

ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY (ISSN 1079-5642) is published monthly by Lippincott Williams & Wilkins, at 16522 Hunters Green Parkway, Hagerstown, MD 21740. Business offices are located at Two Commerce Square, 2001 Market St., Philadelphia, PA 19103. Production offices are located at 351 West Camden Street, Baltimore, MD 21201-2436. For institutional rates in Japan, contact Igaku-Shoin MYW, Ltd., 3-23-14 Hongo, Bunkyo-ku, Tokyo 113, Japan. Individuals may subscribe for their personal use at the following annual rates: $217 for members of an American Heart Association scientific council and $381 for nonmembers; international: $266 for members of an American Heart Association scientific council and $451 for nonmembers. Periodicals postage paid at Hagerstown, MD and additional mailing offices. POSTMASTER: Send address changes to ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY, American Heart Association, Lippincott Williams & Wilkins, 12107 Insurance Way, Hagerstown, MD 21740. Key: VB Vascular Biology AL Atherosclerosis/Lipoproteins TH Thrombosis

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Expression Pattern of Alternative Splicing Variants of Human Telomerase Reverse Transcriptase (hTERT) in Cancer Cell Lines Was not Associated with the Origin of the Cells

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Regulation of telomere length and homeostasis by telomerase enzyme processivity.

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The non-reverse transcriptase activity of the human telomerase reverse transcriptase promotes tumor progression (review).

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Telomerase activity and hTERT protein expression in meningiomas: an analysis in vivo versus in vitro.

BACKGROUND Telomere length maintenance is essential for tumorigenesis. Most human tumours stabilise their chromosome ends by telomerase, a specialised reverse transcriptase that adds telomeric repeats (TTAGGG) to these ends. The main components of this telomerase complex are a reverse transcriptase (hTERT) and an integral RNA component (hTR). Most typical meningiomas, however, do not have activ...

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Structural elements required for association of the Saccharomyces cerevisiae telomerase RNA with the Est2 reverse transcriptase.

Telomere synthesis in most organisms depends on the action of the telomerase enzyme, which contains an RNA subunit that is stably associated with the reverse transcriptase subunit as well as additional telomerase proteins. In the budding yeast Saccharomyces cerevisiae, several structural domains that are responsible for mediating protein interactions with the telomerase RNA TLC1 have been ident...

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عنوان ژورنال:
  • Arteriosclerosis, thrombosis, and vascular biology

دوره 31 2  شماره 

صفحات  -

تاریخ انتشار 2011